Yamashita T, et al. - In patients with severe acute pancreatitis (SAP), researchers assessed the connection between the volume of fluid administered and clinical results by conducting a multicenter retrospective study at 44 institutions in Japan. Inclusion criteria were 18 years of age or older and from 2009 to 2013 were diagnosed with SAP. Study participants were stratified into two groups: administered fluid volume <6000 and ≥6000 mL in the first 24 hours. Data reported that overall in-hospital mortality was 12.3%. According to this multicenter retrospective study, the fluid ≥6000 mL group had significantly higher mortality vs the fluid <6000 mL group. Investigators found no significant link between the administered fluid volume and pancreatic infection or between the volume administered and the need for surgical intervention. Overall, the investigators concluded that the administration of a large fluid volume within the first 24 hours was linked to reduced mortality in patients with SAP.