Prieto-Torres L, Manso R, Cieza-Díaz DE, et al. - Researchers sought to study the presence of large CD30+ cells with Hodgkin-like features and their significance in primary cutaneous marginal zone B-cell lymphomas. Thirteen cases (10 male and 3 female patients) of primary cutaneous marginal zone lymphomas featuring > 10% of CD30+ large cells were examined for the main clinical, histologic, immunophenotypic, and molecular characteristics. Four cases presented with early-local disease and 8 with locoregional advanced disease without extracutaneous involvement but with a high relapse rate of 69%. A high level of CD30 expression was observed to be associated with disease progression, with increased clinical recurrence in cases with > 15% of CD30+ cells. The differential diagnosis with other cutaneous and systemic lymphomas, particularly Hodgkin lymphoma, were also discussed.