Cabré N, et al. - Researchers studied the modulation of hepatic indices of oxidative stress and inflammation in obese patients undergoing laparoscopic sleeve gastrectomy (LSG) to examine the molecular mechanisms of hepatic alterations and to identify molecules that could be used as potential therapeutic targets. Study participants included 436 patients attending the obesity clinic who had LSG for weight loss. One year after surgery, there has been a significant reduction in the incidence of diabetes, dyslipidemia and hypertension. The findings demonstrate that patients with morbid obesity have considerably enhanced histology and liver function after LSG through mechanisms involving a decrease of oxidative stress and inflammatory processes. These data promote the use of LSG as a therapeutic alternative for non-alcoholic fatty liver disease improvement or resolution.