Liu F, et al. - Researchers presented the case of a 58-year-old cirrhotic woman with hepatocellular carcinoma (HCC) located in the paracaval portion of the caudate lobe on whom laparoscopic total caudate lobectomy was performed. The woman suffered from hepatitis C virus-related cirrhosis and underwent preoperative computed tomography indicating a 2.5 × 2.0 cm liver mass located in segment I that was very close to the right hepatic pedicle. Although her liver function was Child–Pugh A, high indocyanine green-15 test at 10.9% was reported. Because of the severe cirrhosis and the elevated ICG-15, laparoscopic isolated total caudate lobectomy but not right hepatectomy plus caudate lobectomy was adopted. An operative time of 300 minutes and the total Pringle time of 50 minutes was reported. The uneventful postoperative course of this patients supports the feasibility and safety of a laparoscopic isolated total caudate lobectomy for HCC located in the paracaval portion of the cirrhotic liver in selected patients.