Zhang Y, et al. - Herein, rheumatoid arthritis (RA) patients were examined for the expression of the inhibitory receptor, leukocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1) in fibroblast-like synoviocytes (FLS), to ultimately investigate the potential role of LAIR-1 in the modulation of inflammatory cytokines, metalloproteinases (MMPs), and invasiveness of synoviocytes. In this study, LAIR-1 was recognized as an anti-inflammatory molecule, and its upregulation in FLS was noted in RA population; however, researchers observed that cell-surface LAIR-1 could be shed from cells in the inflammatory microenvironment in RA. Overall, findings suggested that LAIR-1 may be a crucial factor involved in the mediation of the progressive joint destruction in RA.