Zhang J, Han F, Liang X, et al. - In this study, the risk factors and risk of stroke were compared between lacune and large perivascular spaces (PVSs) in a community-based sample. Researchers evaluated large PVSs applying 3.0T MRI in a population-based cohort consisting of 1,204 participants. The univariate and multivariable ordinal logistic regression analysis were applied to evaluate the relationship between cardiovascular risk factors, neuroimaging changes, and incidental stroke risk, and the presence of lacune or large PVSs. The lack of relationship between large PVSs and cardiovascular risk factors or risk of stroke demonstrated a nonvascular pathogenic mechanism underlying large PVSs, implying the utility of identifying large PVSs from lacunes in clinical practice.