Fatheree NY, et al. - This trial discerned the safety of probiotic Lactobacillus reuteri (L reuteri) strain Deutsche Sammlung von Mikroorganismen (DSM) 17938 with daily administration to healthy infants with colic. The impact of L reuteri strain DSM 17938 on crying, fussing, inflammatory, immune, and microbiome variables were also explored. It was inferred that its daily administration was safe in newborn infants with colic, including those with neutropenia, which coexisted often. A placebo response of 66% was indicative of several infants with colic reporting resolution within 3 weeks.