Zhou L, et al. - Individuals with symptomatic knee OA (n = 1,168) from the Osteoarthritis Initiative were involved in order to evaluate the correlation between beta-blocker use and knee pain, areas of joint pain, and analgesic use among people with symptomatic knee OA. With an estimated within-person variation of 0.1, beta-blocker users had comparable estimated mean WOMAC pain scores as other anti-hypertensive users. The proportion of individuals reporting widespread joint pain was comparable among beta-blocker users and other anti-hypertensive users. Among beta-blocker users and other anti-hypertensive users, reported use of strong prescription pain medication was also comparable. In conclusion, among individuals with symptomatic knee OA, evidence that beta-blockers present a clinically significant decrease in knee pain severity, areas of joint pain, or analgesic use could not be observed.