Hoiland RL, Sekhon MS, Cardim D, et al. - In hypoxic ischemic brain injury (HIBI) patients, invasive monitoring of cerebral autoregulation using the pressure reactivity index (PRx) enables the determination of optimal mean arterial pressure (MAP^OPT) following cardiac arrest. Researchers here examined the agreement between PRx-derived MAP^OPT vs MAP^OPT determined by the near-infrared spectroscopy (NIRS) based cerebral oximetry index (COx). They compared PRx-derived MAP^OPT, lower (LLA) and upper limits of autoregulation (ULA) against COx-derived MAP^OPT, LLA and ULA. Mean arterial pressure, intracranial pressure, brain tissue oxygenation, jugular venous oxygen saturation, and NIRS-derived regional cerebral oxygen saturation were included in multimodal neuromonitoring. Enrollment of 10 HIBI patients was done. Per findings, COx-based determination of MAP^OPT lacks agreement with MAP^OPT derived from PRx.