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Laboratory‐wide association study of survival with prostate cancer

Cancer Dec 07, 2020

Sohlberg EM, Thomas IC, Yang J, et al. - In order to find out the relationships between routinely collected laboratory tests and survival in veterans with prostate cancer, researchers used XWAS methods, hereafter referred to as “laboratory‐wide association study (LWAS).” Between 2000 and 2013, they found 133,878 individuals who were diagnosed with prostate cancer in the Veterans Health Administration via any laboratory tests collected within 6 months of diagnosis (3,345,083 results). The study found routinely collected laboratory data was correlated with survival for individuals with prostate cancer applying LWAS methodologies, including markers of prostate cancer biology, overall health, and inflammation. Researchers identified 31 laboratory tests that were correlated with survival that can help inform the design of clinical trials and aid patients in shared decision making using. These included prostate‐specific antigen, alkaline phosphatase, serum albumin, and erythrocyte sedimentation rate, among others.

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