Maria DS, et al. - Because evidence suggests that young adults experiencing homelessness (YEH) are at high risk of HIV vs housed youth, researchers analyzed their knowledge and attitudes about pre-exposure prophylaxis (PrEP). They used data from a cross-sectional survey among YEH (ages 18–26) (n = 1,427) in seven U.S. cities to evaluate their knowledge and attitudes about PrEP to inform HIV prevention efforts. Participants (mean age was 20.9years) in the study were primarily male youth of color. This study's findings suggest missed opportunities for YEH to prevent new HIV infections. Efforts to increase the uptake of PrEP among this population should consider interventions at the provider and system level to increase awareness of PrEP, decrease the costs associated with PrEP healthcare, improve access to PrEP providers, and provide support for in-person and text messaging.