Wallace IJ, Felson DT, Worthington S, et al. - Experts asserted that knee OA is one such disease for which susceptibility is augmented by this energy balance transition. Irrespective of having significantly lower obesity levels vs the Americans, the Tarahumara seemed inclined to accrue greater abdominal adiposity (ie, larger abdomens) for provided body weight, and were more exposed to radiographic and symptomatic knee OA at lower levels of BMI. Additionally, proportionate raised in the abdomen size in the two groups were related to bigger advances in radiographic knee OA risk among the Tarahumara compared with the Americans, suggesting that the abdominal adipose tissue of the Tarahumara is a more efficient stimulus for knee degeneration. Therefore, among non-industrial societies encountering active lifestyle shifts, increased vulnerability to knee OA is a matter that assures additional investigation as such groups designate a large yet understudied portion of the global population.