Roy S, et al. - In this study, researchers examined 102 patients with oral squamous cell carcinoma (OSCC) for the role of octamer-binding transcription factor 4 (OCT4) and Kruppel-like factor 4 (KLF4) in the disease progression and relapse. As per Kaplan-Meier and COX regression analyses, there was an independent association of increased expression of KLF4 in the cut margin region of recurrent patients with a poor prognosis. Findings suggest the utility of expression of KLF4 for monitoring disease progression and its prognostic value to predict recurrence.