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Kinetics of viral clearance and antibody production across age groups in children with severe acute respiratory syndrome coronavirus 2 infection

The Journal of Pediatrics Oct 06, 2020

Bahar B, Jacquot C, Mo YD, et al. - Via performing this retrospective analysis of children tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcription (RT) polymerase chain reaction (PCR) and immunoglobulin G antibody, researchers sought to enhance their understanding concerning the transition from viral infection to viral clearance, and antibody response in pediatric patients with SARS-CoV-2 infection. They assessed 6,369 patients who underwent PCR testing and 215 patients who underwent antibody testing. Viral shedding was observed for a median duration of (RT-PCR positivity) 19.5 days and time from RT-PCR positivity to negativity was 25 days. Observations revealed a prolonged period of viral shedding after infection with SARS CoV-2 in the majority of patients. It is unclear if this correlates with persistent infectivity. Adequate neutralizing antibodies were noted in only 17 of 33 patients during the time frame of specimen collection. It remains unclear if immunoglobulin G antibody against spike structured proteins associates with immunity, and how long antibodies and potential protection persist.

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