Srivastava A, Cai X, Lee J, et al. - This study was undertaken to investigate whether and how kidney functional MRI needs further evaluation to improve the noninvasive identification of patients at high risk of chronic kidney disease (CKD) progression. Researchers conducted exploratory study to collect baseline diffusion-weighted and blood oxygen level–dependent MRI in 122 participants of the CKD Optimal Management with Binders and Nicotinamide trial, which was a multicenter, randomized, double-blinded, 12-month, four-group parallel trial of nicotinamide and lanthanum carbonate vs placebo performed in individuals with eGFR 20–45 ml/min per 1.73 m². The data showed that baseline cortical ADC was correlated with change in eGFR over time, but this correlation was not independent of albuminuria. Kidney functional MRI biomarkers remained stable over 1 year.