Xie ZH, et al. – Researchers wanted to figure whether KIAA1522 overexpression promoted tumorigenicity and metastasis of esophageal cancer cells through potentiating the extracellular signal-regulated kinase (ERK) activity. Via potentiating the ERK activity, upregulation of KIAA1522 appeared to enhance tumorigenicity and metastasis of esophageal squamous cell carcinoma (ESCC) cells. In light of these findings, they suggested the oncogenic roles of aberrant expression of KIAA1522 in ESCC. Moreover, it seemed to serve as a novel molecular target in ESCC treatment.