Mankowitz SL, et al. - Researchers investigated the safety and efficacy of ketamine for sedation of prehospital and emergency department (ED) patients with undifferentiated agitation via a systematic review. They analyzed 1,176 results from 14 databases and assessed that ketamine is efficacious in providing rapid sedation for undifferentiated agitated patients and is correlated with higher intubation rates when used by ground emergency medical services paramedics, vs ED or air medical transport patients. They observed the common occurrence of other side effects, but these were usually self-limiting.