Bai JDK, Babu S, Roa-Peña L, et al. - Gene expression data (mRNA) from The Cancer Genome Atlas were examined for 271 high-grade endometrial carcinomas and K17 immunohistochemistry (IHC) was performed on a separate cohort of 119 high-grade endometrial cancer cases from two academic medical centers in order to ascertain whether K17 mRNA and protein levels related to reduced survival of people with high-grade endometrial cancer. High K17 mRNA and IHC related to reduced overall survival. In malignant glandular cells of the endometrium, K17 was positive, although, not in other tissues, such as endometrial stroma, myometrium, and uterine sarcoma. Results strengthen the outcome that K17 is a negative prognostic biomarker in high-grade endometrial carcinoma and that K17 IHC test results could be utilized to notify decisions associated with therapeutic intervention.