Joint effect between bisphenol A and alcohol consumption on benign prostatic hyperplasia: A case–control study in Hong Kong Chinese males
The Prostate Sep 06, 2021
Liao G, Lee PMY, Zhao S, et al. - An increased benign prostatic hyperplasia (BPH) risk in relation to chronic oral bisphenol A (BPA) exposure was observed with a positive exposure–response association among Hong Kong Chinese, and the impact of BPA on BPH was amplified by alcohol intake.
A total of 650 BPH cases and 650 controls were included from the same hospital in Hong Kong, and were examined with a validated cumulative BPA exposure index (CBPAI).
A positive exposure–response link was evident between CBPAI and BPH risk.
Frequent BPA exposure through oral consumption of foods heated in a plastic box/bag (odds ratio [OR] = 3.52), cooling water in a plastic bottle (OR = 2.65), or using a plastic cup to contain hot water (OR = 4.14), was significantly related to elevated BPH risk.
An additive interaction between CBPAI and alcohol on BPH risk was indicated.
To mitigate BPH risk, there should be minimizations of containing food or water/beverage in plastic containers and drinking alcohol.
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