Alahari S, et al. - The effects of iron availability in regulating JMJD6 function in preeclampsia was investigated in this study. This study provides evidence that exuberant placental ceruloplasmin activity may contribute to increased iron efflux into the maternal circulation, thereby limiting intracellular Fe2+ bioavailability. This, in turn, influenced JMJD6 histone demethylase activity, with implications for epigenetic regulation of hypoxic gene expression program.