Hashimoto T, Nattkemper LA, Kim HS, et al. - Researchers sought to explore the association between itch intensity in prurigo nodularis (PN) and the expression of a pruritogenic cytokine interleukin (IL)‐31, its receptor complex components IL‐31 receptor α (IL‐31RA) and oncostatin M receptor β (OSMRβ), and oncostatin M (OSM), which is a ligand of OSMR β, through immunofluorescence staining examination. The study results showed that IL‐31 (mainly from macrophages and T cells) and OSM (mainly from T cells and mast cells) stimulate dermal cells expressing IL‐31RA and OSMRβ (eg, macrophages), which can further promote itch and inflammation in PN. This complex dermal milieu of cell/cytokine/receptor network may be a therapeutic target for PN‐associated itch.