Wicke FS, et al. – Because guideline-recommended stroke-risk assessment by CHA2DS2-VASc-score differs by setting and region in patients with atrial fibrillation (AF), researchers estimated ischemic stroke risk (stratified by the CHA₂DS₂-VASc-score) using a broadly representative population with AF from southern Germany, and compared them to findings from previous studies. Compared with internationally published data, different performance of the CHA₂DS₂-VASc-score was evident in the German population; an overall trend towards a lower risk of ischemic stroke in uncoagulated AF patients was observed.