Huang XX, Jiang RH, Xu XD, et al. - This study was sought to explore the impacts of ischemic stroke on gadolinium (Gd) deposition in the brain following repeated administration of linear or macrocyclic Gd‐based contrast agents (GBCAs) and to ascertain if GBCAs aggravate astrocyte injury after stroke. Researchers randomized 27 male Sprague–Dawley rats to an exposure group (n = 24) and a healthy control group (n = 3). They conducted a one‐way analysis of variance and two‐sample t‐tests. The results of this study demonstrated that administration of GBCAs following an animal model of ischemic stroke elevated Gd deposition in the brain and aggravated astrocyte injury. The impact of gadopentetate seemed to be more pronounced than that of gadobutrol.