Natsuaki M, Morimoto T, Watanabe H, et al. - Researchers determined the impact of prior hemorrhagic (n = 285) or ischemic stroke (n = 1,773) vs no-prior stroke (n = 17,417) on ischemic and bleeding outcomes post-percutaneous coronary intervention (PCI), using a pooled cohort including 19,475 patients from 3 Japanese PCI studies. They noted that in the prior hemorrhagic and ischemic stroke groups vs in the no-prior stroke group, there were higher cumulative 3-year incidences of the co-primary bleeding endpoints of intracranial hemorrhage, non-intracranial global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries moderate/severe bleeding, and the primary ischemic endpoint of ischemic stroke/myocardial infarction. Findings revealed a higher risk for intracranial hemorrhage and ischemic events, but not for non-intracranial bleeding post-PCI in patients with prior hemorrhagic or ischemic stroke vs those with no-prior stroke.