Ekström K, Nielsen JVW, Nepper-Christensen L, et al. - Researchers used a large contemporary cohort of ST-segment–elevation myocardial infarction (STEMI) patients, to determine the link between functional significant, multivessel disease (MVD) and decreased culprit final infarct size or increased myocardial salvage (myocardial salvage index [MSI]) in this population. They conducted cardiac magnetic resonance in 610 STEMI patients at day 1 and 3 months post-primary percutaneous coronary intervention. Single vessel disease (SVD) was detected in 431 (71%) patients, functional SVD was present in 35 (6%), and functional MVD in 144 (23%). Findings revealed that functional MVD in nonculprit myocardium was not related to decreased culprit final infarct size or increased MSI post-STEMI.