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Is the lower risk of venous thromboembolism with statins related to low-density-lipoprotein reduction?: A network meta-analysis and meta-regression of randomised controlled trials

Atherosclerosis Evidence based | Mar 07, 2018

Zaccardi F, et al. - Researchers, using data from randomised controlled trials (RCTs), evaluated differences among statins with respect to benefits on the risk of venous thromboembolism (VTE). They also examined the link between risk of VTE and reduction of low-density-lipoprotein-cholesterol (LDL-c) levels. A partial association of reduced VTE risk with LDL-c reduction was demonstrated in RCTs with statin treatment. Also, data showed that the benefit was larger than that observed for atherothrombotic risk. Network meta-analysis indicated a larger benefit for rosuvastatin compared to placebo and other statins.
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