Boonprasert K, et al. - This study was designed to test the hypothesis that cadmium (Cd) exposure alters renal production of 20-hydroxyeicosatetraenoic acid (20-HETE), which plays an indispensable role in renal salt balance and blood pressure control. For the first time, it was reported herein that urinary 20-HETE levels are associated with blood pressure increases in Cd-exposed women, thereby offering a plausible mechanism for the associated development of hypertension.