Is rapid eye movement sleep behavior disorder a risk factor for impulse control disorder in Parkinson disease?
Annals of Neurology Aug 19, 2020
Fantini ML, Fedler J, Pereira B, et al. - In patients with early Parkinson disease (PD), researchers explored the connection between rapid eye movement sleep behavior disorder (RBD) and other determinants and incident impulse control disorder behaviors (ICBs) utilizing longitudinal data from the Parkinson's Progression Markers Initiative. They prospectively assessed 401 patients newly diagnosed with PD at baseline (BL), 6 months, and then annually for 5 years. Probable RBD (pRBD) was evaluated with the RBD Screening Questionnaire and dichotomized using a cutoff value of ≥ 6. After adjustment for covariates, BL pRBD as well as time‐dependent pRBD were not linked to an increased risk for incident ICB symptoms. In comparison, use of a dopamine agonist, depression, and male sex is linked to ICB symptom development in early PD.
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