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Is antibiotics prescription needed in infants with topical corticosteroids treatment for moderate‐to‐severe atopic dermatitis?

Dermatologic Therapy Aug 26, 2020

Liu Y, Zhou Q, Dai W, et al. - Researchers conducted the study for analyzing the microbiota impact in atopic dermatitis children under therapy with topical corticosteroids and antibiotics. Fifty-nine atopic dermatitis patients were randomized to two treatment groups (by corticosteroids or combination therapy) in Beijing Children's Hospital. The lesion microbial samples were obtained for 16S rDNA sequencing and bioinformatics analysis. Fifty-seven patients recovered significantly after treatment. Though topical antibiotics application blocked the restoration of commensal Streptococcus, no remarkable differences of cutaneous microbiota have been identified between the two groups along with treatment. The preliminary research indicated the need for consideration of the profile of cutaneous microbiota when prescribing antibiotics.

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