Landgraf-Rauf K, et al. - This study investigated the impact of interferon regulating factor 1 (IRF-1) polymorphisms (SNPs) on distinct immune regulatory pathways in allergic and non-allergic childhood asthma (AA/NA). Findings demonstrated an association of IRF-1 polymorphisms with increased pro-inflammatory gene-regulation and in turn, their impact on the risk of childhood allergic asthma. This finding necessitated the implementation of IRF-1 genetics in immune assessment for childhood asthma phenotypes.