van Assen M, et al. - In this study involving 42 patients, researchers evaluated the efficacy of rest-stress dual-energy computed tomography (DECT) iodine quantification in delineating normal, ischemic, and infarcted myocardium. They included a retrospective sample of patients who were enrolled in a prospective study cohort. These patients underwent rest-stress DECT on a 2nd generation dual-source system and cardiac magnetic resonance (CMR). Investigators found that iodine concentrations increased significantly from rest to stress in normal myocardium. For differentiating diseased from normal myocardium, the optimal thresholds were 2.5 mg/mL and 2.1 mg/mL for rest and stress, respectively. To discriminate ischemic from infarcted myocardium, the optimal threshold was 1.0 mg/ml at rest. According to findings, DECT iodine concentration from rest-stress imaging may be able to distinguish between normal, ischemic, and infarcted myocardium.