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Involvement of MAF/SPP1 axis in the development of bone marrow fibrosis in PMF patients

Leukemia Aug 16, 2017

Ruberti S, et al. – This study was designed to assess the involvement of MAF/SPP1 axis in the development of bone marrow fibrosis in primary myelofibrosis (PMF) patients. Via driving the deranged production of the profibrotic mediator SPP1, MAF overexpression contributed to PMF pathogenesis.
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