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Involvement of DPP9 in gene fusions in serous ovarian carcinoma

BMC Cancer Sep 15, 2017

Smebye ML, et al. - In order to determine novel fusion gene candidates and aberrantly expressed genes in ovarian carcinomas, genomic and transcriptomic information was combined. This study recognized novel fusion gene candidates in high-grade serous ovarian carcinoma. Results revealed the involvement of dipeptidyl-Peptidase 9 (DPP9) in two different fusion transcripts that both resulted in deregulated expression of the 3' end of the transcript and thus possible loss of the active domains in the DPP9 protein. This study highlighted the potential role of identified rearrangements in tumorigenesis or tumor progression.
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