Saboute M, et al. - Via a case-control study conducted on 64 neonates hospitalized in Akbar Abadi Hospital and their 64 mothers, the researchers assessed the association between maternal 25-hydroxyvitamin D3 serum levels and neonatal early-onset sepsis (systemic bacteremia with positive blood or cerebrospinal fluid culture in the first 7 days of neonate’s life and a dangerous complication with relatively lesser incidence) in newborns by the effective factors. The case group had 32 neonatal intensive care unit term hospitalized neonates because of neonatal early-onset sepsis. A notable association between sepsis and older age of mothers and the low Apgar scores was found. The maternal vitamin D serum level was reversely associated with neonatal sepsis occurrence. A meaningful relationship among maternal vitamin D supplement consumption during pregnancy and lower risk for neonatal sepsis was ascertained. Hence, the level of maternal serum Vitamin D was inversely associated with neonatal sepsis occurrence and consumption of vitamin D supplements during pregnancy could reduce the risk of early neonatal sepsis.