Kushner P, Peach E, Wittbrodt E, et al. - This article outlines the methods and rationale for a multinational, multifocal observational study named REVEAL-CKD which is expected to enhance awareness regarding the worldwide clinical and financial burden of undiagnosed stage 3 chronic kidney disease (CKD). In addition, this study will offer valuable insights to inform clinical practice and policy changes.

• Using selected secondary databases from 11 countries, patients (aged ≥ 18 years) with at least two estimated glomerular filtration rate measurements from 2015 onwards that are ≥ 30 and < 60 mL/min/1.73 m ² , recorded > 90 and ≤ 730 days apart, will be included.

• A Kaplan–Meier approach and adjusted logistical regression analyses will be used.

• In REVEAL-CKD, the focus will be on the point prevalence of undiagnosed stage 3 CKD and time to CKD diagnosis in initially undiagnosed cases overall as well as in separate countries.

• Another target will be to evaluate trends in undiagnosed CKD prevalence by calendar year.

• Furthermore, patients with a CKD diagnosis will be compared with those without a CKD diagnosis, in terms of patient characteristics, healthcare resource use, adverse clinical results, and CKD management and monitoring practices.