Huang CH, Su YC, Chang CC, et al. - This study was undertaken to explore the relationship between antibody responses to human papillomavirus (HPV)16 E7 and head and neck cancer (HNC) risk in a hospital‐based case-control study conducted in Taiwan with 693 HNC cases and 1,035 controls. Researchers observed a positive association between seropositivity to HPV16 E7 and oropharyngeal cancer (OPC) risk, whereas there was no significant relationship in the non‐OPC cases. The results implied that similar to Western countries, HPV may also be an important risk factor of OPC in Taiwan. According to the results, with the declining consumption of betel quids and cigarettes in Taiwan, a higher percentage of OPC cases in Taiwan will be attributed to HPV in the future. There is a need for public health measures, including HPV vaccination for the prevention of the occurrence of HPV‐positive OPC.