Tavakolpour S, Mahmoudi H, Karami F, et al. - In the present study, the researchers sought to examine the expression of aforementioned critical immune system-related genes, including CTLA4, PDCD1, TNFSF13B, FCGR3A, EBI3, IL9, IL21, and IL22 genes in pemphigus patients compared with healthy controls, as well as monitoring the changes of these genes in patients 3 months after rituximab (RTX) infusion. Higher prednisolone dosage and PDAI‐score have been positively associated with CTLA4 and FCGR3A expressions after 3 months, respectively. Anti‐desmoglein 1 (Dsg 1) titer and its positivity at baseline were linked to TNFSF13B expression, FCGR3A expressions, and the PDAI‐score. The findings indicate the potential involvement in pemphigus immunopathogenesis of certain gene expressions, which could be affected by RTX therapy and could also be used as prognostic biomarkers.