Carstensen–Kirberg M, et al. – A large population–based cohort was assessed for characterization of associations of circulating secreted frizzled-related protein (SFRP)5 with cardiometabolic risk factors and prediabetes/type 2 diabetes. An inverse link was reported, between higher serum SFRP5 and multiple risk factors for type 2 diabetes and cardiovascular diseases. However, body mass index (BMI) represented a strong confounder of some of these links. Independent of BMI, higher circulating SFRP5 was also related to lower odds of prediabetes/type 2 diabetes.