Lauten M, et al. - In this retrospective multicenter analysis, researchers examined contemporary central nervous system (CNS) invasive mold disease (IMD) cases in immunocompromised children and adolescents with emphasis on clinical presentation and outcome. A total of 29 subjects with proven (n=12) or probable (n=17) CNS IMD were diagnosed. Data reported that overall survival was 49%, which is comparable to a recent series of adult patients' survival rate, but significantly higher than the overall survival of 35% reported in the review of CNS aspergillosis treated children between 1955 and 2005. According to findings, the outcome of CNS IMD in children has improved vs previous series, half of surviving patients suffer from severe neurological sequelae, and CNS imaging should be done in all children with IMD regardless of neurological symptoms.