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Introduction of a novel quantitative scoring system for acanthosis nigricans and its validation in a pilot study

Dermatologic Therapy Oct 29, 2020

Karadag AS, Uzuncakmak TK, Ozlu E, et al. - In an outpatient department‐based prospective study, researchers designed a scoring for acanthosis nigricans (AN) severity to assess AN and skin tags, their correlation with obesity or diabetes. The quantification of AN at six anatomic sites, taking into account the affected skin surface areas, texture changes, number of skin tags, results in a total severity score between 0 and 46. Among 336 adult patients (aged ≥ 18 years) with AN, a higher BMI was linked to AN, but not with diabetes, as compared with 243 age‐ and sex‐matched controls without AN. The findings show that it is possible to use a combination of AN with skin tags as a clinical marker for obesity, but not for diabetes. Large‐scale studies on patients of different ethnic background are needed to further validate the proposed scoring.

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