Rosenbaum AN, et al. - Researchers sought to evaluate the correlation between intrinsic myocardial function and reverse remodeling or LVAD unloading. Patients implanted with continuous flow LVADs who underwent combined LHC/RHC ramp protocol were assessed for hemodynamic data including peak LV dP/dt and tau. They identified a cohort of 62 patients undergoing LHC/RHC study; of these, 25 were included (12 with LVEF ≥ 25%, augLV, and 13 with LVEF < 25%, impLV). They observed important hemodynamic differences between augLV and impLV; the differences included aortic pulse width, tau, and peak LV dP/dt. Findings revealed significant associations between intrinsic myocardial function and reverse remodeling as well as aortic pulsatility. They observed a greater reliance on LVAD for unloading at greater speeds, indicating excessive LVAD unloading as possibly detrimental.