Vidiri A, Marzi S, Gangemi E, et al. - A total of 73 patients with a new diagnosis of oropharyngeal squamous cell carcinoma (OPSCC) were recruited in order to examine the associations between imaging parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and HPV status in OPSCC. Sixty-seven primary tumors (PTs) and 67 metastatic lymph nodes (LN) were investigated. Important variations in ADC and tissue diffusion coefficient (D_t) values among HPV-positive and HPV-negative patients were obtained for PTs, while a trend toward importance in Dt was proclaimed for LNs. The perfusion-related parameters, perfusion fraction (f), D* and D*× f, had no association with HPV status. The best auspicious model for HPV positivity was achieved combining alcohol consumption and smoke habits with D_t values of PTs. In conclusion, between IVIM-DWI and HPV status in OPSCCs notable associations were detected. The perfusion-free diffusion coefficient, D_t, may better highlight the HPV-related tumor variations in comparison with ADC, whereas the perfusion-related parameters could not dependably distinguish HPV-positive from HPV-negative OPSCC.