Chaves L, Messias A, Correa Z, et al. - Researchers conducted the study for evaluating the safety and early outcome of intravitreal metoprolol tartrate in five patients with circumscribed choroidal hemangiomas (CCH). Five patients (5 eyes) with subfoveal or peripapillary CCH who had been unsuccessfully treated with intravitreal anti-VEGF agents were participated in this study and received off-label intravitreal injections of metoprolol (50μg/0.05 ml). Patients with CCH who received a single intravitreal metoprolol injection of 50μg/0.05ml showed no signs of acute ocular toxicity. The long-term retinal toxicity, different concentrations, drug resistance, and complications from repeated-intravitreal injections were not assessed in this pilot study.