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Intravenous pulses of methylprednisolone for infants with severe bronchopulmonary dysplasia and respiratory support after 3 months of age

Pediatric Pulmonology Oct 23, 2020

Billion E, Hadchouel A, Garcelon N, et al. - Since there are few published data on the effectiveness of systemic corticosteroids in preterm infants with very severe forms of bronchopulmonary dysplasia (BPD), requiring respiratory support after 3 months of age, researchers reported the use of pulses of methylprednisolone in this population and its consequences on the level of respiratory support. The sample consisted of infants (n = 10) over 3 months of age with severe BPD who received at least one pulse of methylprednisolone (300 mg/m2/day intravenous [IV] over 3 days). According to this retrospective monocentre study, high‐dose IV pulses of methylprednisolone have been correlated with a reduction in the level of respiratory support needed by infants with very severe forms of BPD, with a greater effect in those on mechanical or noninvasive ventilation.

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