Di M, et al. - Researchers herein investigated the impacts of different doses of intravenous dexmedetomidine pre-medication on minimum alveolar concentration of sevoflurane for smooth tracheal extubation (MAC_EX) in anesthetized children. They found that in a dose-dependent manner, dexmedetomidine decreased the required MAC_EX values of sevoflurane to achieve smooth extubation. Furthermore, they noted that intravenous dexmedetomidine 1 μg/kg and 2 μg/kg pre-medication decreased MAC_EX by 41% and 64%, respectively.