Martínez MJ, et al. – Researches conducted this investigation to study the contribution of contrast-enhanced ultrasound (CEUS) to improve the results of US in the evaluation of recurrence in postsurgical Crohn’s disease (CD) and established its role in the assessment of the severity. In 108 postsurgical CD patients with B-mode, color Doppler and CEUS, anastomotic site was evaluated. To establish the best cutoff to predict recurrence and the severity, a receiver operating characteristic (ROC) curve was built. Ileocolonoscopy found recurrence in 90 (83.3%) participants and severe recurrence in 62. In the detection of endoscopic recurrence, wall thickness (WT) ≥ 3 mm had an accuracy of 90.7%. The combination of parameters—WT ≥ 3 mm and bowel wall contrast enhancement (≥ 46%)—showed similar accuracy (90.7%). A WT ≥ 5 mm exhibited the best specificity (100%) for recurrence diagnosis, and a WT ≥ 6 mm showed the best specificity (95.7%) for severe recurrence detection. For the diagnosis of postsurgical recurrence, US shows high sensitivity and specificity. It can improve the detection of severe recurrence when combined with CEUS.