Fantasia I, Bussani R, Gregori M, et al. - This study was undertaken to evaluate whether limiting factors of intrauterine magnetic resonance imaging (iuMRI) conducted in the early second trimester of pregnancy (19-23 weeks) influence its accuracy in comparison to post-mortem MRI (pmMRI) in fetuses that underwent termination of pregnancy (TOP) for central nervous system (CNS) defects. A secondary analysis of a 10 years prospective observational study was conducted to include cases of TOP < 23 weeks for CNS malformation that underwent neurosonography (NSG), iuMRI, pmMRI and autopsy. Researchers included a total of 143 TOPs for fetal congenital anomaly who had undergone the post-mortem diagnostic protocol. This study's findings demonstrate limiting factors that might influence the performance of iuMRI have little influence on iuMRI accuracy for CNS defects at 19-23 weeks. Evidence is especially beneficial for professionals who work in countries with legal bound for TOP in the early second trimester.