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Intratympanic mixture gentamicin and dexamethasone vs dexamethasone for unilateral Meniere disease

American Journal of Otolaryngology - Head and Neck Medicine and Surgery Sep 03, 2019

Öztürk K, et al. - In this study including 38 patients with intractable Meniere disease, researchers identified the efficacy of an intratympanic (IT) injection of a mixture of gentamicin and dexamethasone vs intratympanic dexamethasone (ITD) in controlling vertigo and protecting hearing levels in patients with Meniere disease who have persistent vertigo attacks despite medical treatment. Twenty-one patients were treated with IT mixture gentamicin and dexamethasone injection and 17 patients were treated with ITD. Findings revealed that there was better control of vertigo in the mixture group 2 years after IT treatment than in the ITD group. In intractable cases of Meniere disease, IT injection of a mixture of gentamicin and dexamethasone is more effective than ITD for vertigo control. There has been no worsening in the ITD group hearing.
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