Goda E, et al. - Among 35 patients (35 eyes) with primary open-angle glaucoma (POAG), researchers studied the use of ripasudil, defined as effective if drug administration resulted in a greater than 10% decline in intraocular pressure (IOP), as a trabeculotomy outcome marker. Thirty-five eyes had trabeculotomy and were postoperatively followed for over 3 months between May 2015 and December 2018. For this investigation, they divided patients into effective (effective group) or non-effective (non-effective group) ripasudil administration groups. After ripasudil administration, effective IOP reduction occurred in 14 of 35 eyes, which was demonstrated by a decrease of more than 10%. Postoperatively, for up to 24 months, both groups showed significant declines in IOP and antiglaucoma medication use. Findings suggested that trabeculotomy is successful in ripasudil-efficient POAG eyes to achieve an IOP < 21 mmHg. In anticipating surgical outcomes after trabeculotomy, examination of ripasudil’s IOP-lowering effects might be beneficial.