Uusalo P, et al. - A sum of 120 subjects with American Society of Anesthesiologists status 1-2, age between 35 and 80 years were examined to analyze the influence of intraoperatively administered intranasal low-dose dexmedetomidine on postoperative opioid demand in total hip arthroplasty (THA) cases. They found lower mean arterial pressure in the postanesthesia care unit among dexmedetomidine group as compared to the control group. No difference in the postanesthesia care unit stay or postoperative length of stay between the two groups was observed. They also recorded that intraoperative use of intranasal low-dose dexmedetomidine declined the opioid consumption and sympathetic response during the acute postoperative period in THA cases.